3-Chloro-4-fluoro-L-phenylalanine

Base Information

• Chemical Name: 3-Chloro-4-fluoro-L-phenylalanine
• CAS No.: 783241-21-4
• Molecular Formula: C₉H₉ClFNO₂
• Molecular Weight: 217.627
• Mol file: 783241-21-4.mol

Synonyms:3-Chloro-4-fluoro-L-phenylalanine;(2S)-2-AMINO-3-(3-CHLORO-4-FLUOROPHENYL)PROPANOIC ACID

Chemical Property of 3-Chloro-4-fluoro-L-phenylalanine

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

3-Chloro-4-fluoro-L-phenylalanine 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Chloro-4-fluoro-L-phenylalanine

There total 6 articles about 3-Chloro-4-fluoro-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-chloro-4-fluorophenyl)acrylic acid (155814-22-5) → (S)-2-amino-3-(3-chloro-4-fluorophenyl)propanoic acid (783241-21-4,769113-73-7)

Guidance literature:

With ammonium hydroxide; carbon dioxide; In dimethyl sulfoxide; at 37 ℃; for 12h; pH=10; Reagent/catalyst; stereoselective reaction; Enzymatic reaction;

DOI:10.1016/j.tet.2015.12.063

Reference yield:

α-(3-Chlor-4-fluor-benzyl)-α-acetamino-malonsaeure-diethylester (14937-92-9) → β-(3-Chlor-4-fluorphenyl)-α-alanin (7731-00-2,783241-21-4,769113-73-7)

Guidance literature:

With hydrogenchloride; acetic acid; Heating;

DOI:10.1021/jm00313a013

Reference yield:

2-chloro-1-fluoro-4-methylbenzene (1513-25-3) → β-(3-Chlor-4-fluorphenyl)-α-alanin (7731-00-2,783241-21-4,769113-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS, (PhCO)2O₂

2: (i) Na, (ii) /BRN= 2436145/

3: aq. HCl, AcOH / Heating

With hydrogenchloride; N-Bromosuccinimide; acetic acid; dibenzoyl peroxide;

DOI:10.1021/jm00313a013

upstream raw materials:

α-(3-Chlor-4-fluor-benzyl)-α-acetamino-malonsaeure-diethylester

2-chloro-1-fluoro-4-methylbenzene

3-chloro-4-fluorobenzyl bromide

3-amino-4-fluorotoluene