1513-25-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Chloro-4-Fluorotoluene is used as a reagent for the synthesis of pharmaceutical compounds. Its unique structure allows for the introduction of different functional groups, making it a valuable component in the development of new drugs.
Used in Chemical Synthesis:
In the chemical industry, 3-Chloro-4-Fluorotoluene is employed as a reagent for the synthesis of various chemical compounds. Its versatility in introducing functional groups into organic molecules makes it an essential tool in the creation of new chemical entities.
Safety Considerations:

InChI:InChI=1/C7H6ClF/c1-5-2-3-7(9)6(8)4-5/h2-4H,1H3

Upstream product

• 116850-27-2 2-chloro-1,1,2-trifluoro-3-isopropenylcyclobutane 
• 635305-46-3 2-(3-chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 74-88-4 methyl iodide 
• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 78-79-5 isoprene 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 452-84-6 3-amino-4-fluorotoluene 

Downstream Products

• 192702-01-5 3-chloro-4-fluorobenzyl bromide 
• 7731-00-2 β-(3-Chlor-4-fluorphenyl)-α-alanin 
• 14937-92-9 α-(3-Chlor-4-fluor-benzyl)-α-acetamino-malonsaeure-diethylester 
• 1442416-48-9 C₁₅H₁₄ClF 
• 1451144-87-8 2-(3-chloro-2-fluoro-5-methylphenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane 

Relevant academic research and scientific papers

Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes

The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene, or 3,4-difluorotoluene.

Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.