(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine

Base Information

Chemical Name:(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine
CAS No.:223673-35-6
Molecular Formula:C21H26N2O5
Molecular Weight:386.44
Hs Code.:
Mol file:223673-35-6.mol

Synonyms:(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine;[(2R)-2-Hydroxy-2-phenylethyl][2-(4-nitrophenyl)ethyl]carbaMic Acid 1,1-DiMethylethyl Ester;(R)-tert-Butyl (2-hydroxy-2-phenylethyl)(4-nitrophenethyl)carbamate

Suppliers and Price of (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(N-tert-Butoxycarbonyl-N-[(1’R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
10mg
$ 120.00

TRC
(N-tert-Butoxycarbonyl-N-[(1’R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
250 mg
$ 1230.00

Crysdot
(R)-tert-Butyl(2-hydroxy-2-phenylethyl)(4-nitrophenethyl)carbamate 95+%
1g
$ 416.00

Biosynth Carbosynth
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
250 mg
$ 1530.00

Biosynth Carbosynth
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
10 mg
$ 139.80

Biosynth Carbosynth
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
25 mg
$ 254.50

Biosynth Carbosynth
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
100 mg
$ 840.00

Biosynth Carbosynth
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine
50 mg
$ 462.00

Ambeed
(R)-tert-Butyl(2-hydroxy-2-phenylethyl)(4-nitrophenethyl)carbamate 95+%
1g
$ 83.00

Ambeed
(R)-tert-Butyl(2-hydroxy-2-phenylethyl)(4-nitrophenethyl)carbamate 95+%
250mg
$ 32.00

Total 7 raw suppliers

Chemical Property of (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine

Chemical Property:

PSA：95.59000
LogP:4.63120
Storage Temp.:2-8°C
Solubility.:Chloroform

Purity/Quality:

97% ^*data from raw suppliers

(N-tert-Butoxycarbonyl-N-[(1’R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Mirabegron intermediate.

Technology Process of (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine

There total 5 articles about (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 223673-34-5
(R)-2-(4-nitrophenylethylamino)-1-phenylethan-1-ol hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 223673-35-6
((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1248/cpb.58.533

Reference yield:

: 521284-19-5
(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide

: 223673-35-6
((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 70 °C / Cooling with ice

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran;

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 223673-35-6
((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 70 °C / Cooling with ice

3: triethylamine / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;