521284-19-5

Basic information

• Product Name: (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide
• Synonyms: (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide;BenzeneacetaMide, a-hydroxy-N-[2-(4-nitrophenyl)ethyl]-, (aR)-;BenzeneacetaMide, -hydroxy-N-[2-(4-nitrophenyl)ethyl]-, (R)-;R-a-hydroxy-N-[2-(4-nitrophenyl)ethyl]- BenzeneacetaMide;R-alpha-hydroxy-N-[2-(4-nitrophenyl)ethyl]- BenzeneacetaMide;(R)-N-(4-nitrophenethyl)-2-hydroxy-2-phenylacetamide;(R)-2-Hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide;Mirabegron INT 1
• CAS NO: 521284-19-5
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.30924
• EINECS: 300-560-8
• Product Categories: CMLLYL
• Mol File: 521284-19-5.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 584.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.294
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.50±0.20(Predicted)
• CAS DataBase Reference: (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide(521284-19-5)
• EPA Substance Registry System: (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide(521284-19-5)

Safety Data

• Hazardous Substances Data: 521284-19-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 521284-19-5 differently. You can refer to the following data:
1. (ALPHAR)-ALPHA-hydroxy-N-[2-(4-nitrophenyl)ethyl]phenylacetamide is an organic amide, which can be used as a pharmaceutical intermediate.
2. (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is an intermediate used to prepare (aminothiazolyl)acetanilide derivatives via coupling reactions for treatment of diabetes.

InChI:InChI=1S/C16H16N2O4/c19-15(13-4-2-1-3-5-13)16(20)17-11-10-12-6-8-14(9-7-12)18(21)22/h1-9,15,19H,10-11H2,(H,17,20)/t15-/m1/s1

Upstream product

• 611-71-2 (R)-Mandelic Acid 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 
• 24954-67-4 2-(p-nitrophenyl)ethylamine 
• 54385-47-6 (R)-Mandelsaeure, Natrium-Salz 
• 54256-33-6 (R)-(-)-5-phenyl-1,3-dioxolane-2,4-dione 
• 98-86-2 acetophenone 
• 611-73-4 Benzoylformic acid 
• 20698-91-3 (R)-methyl mandelate 

Downstream Products

• 391901-45-4 YM-208876 
• 223673-61-8 (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide 
• 521284-22-0 (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride 
• 223673-36-7 (R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester 
• 223673-35-6 ((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester 
• 223673-34-5 (R)-2-(4-nitrophenylethylamino)-1-phenylethan-1-ol hydrochloride 
• 521284-21-9 (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydrochloride 

Relevant articles and documents

Concise Synthesis of Key Intermediate of Mirabegron via a Mixed Anhydride Method

An efficiently scalable synthesis of key intermediate toward mirabegron has been developed via a mixed anhydride method, employing PivCl instead of EDCI and HOBt. The developed process produced (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide (10) in 91.5-92.3% yield and >99.0% HPLC purity under mild conditions. During this process, a side reaction induced by triethylamine hydrochloride was discovered and investigated, which was ultimately avoided by executing the reaction in a biphasic solvent system.

Aryl or heteroaryl substituted pyrrolidine amide derivatives and application thereof

The invention discloses aryl or heteroaryl substituted pyrrolidine amide derivatives and an application thereof, in particular to a novel aryl or heteroaryl substituted pyrrolidine amide derivative and a pharmaceutical composition containing the same, which can be used for activating beta3-adrenergic receptor. The invention also relates to a method for preparing the compounds and pharmaceutical compositions, as well as an application thereof in preparing drugs for treating diseases or symptoms mediated by beta3-adrenergic receptor, and especially for treating the overactive bladder.

Acyl-substituted pyrrolidine amide derivative and application thereof

The invention discloses an acyl-substituted pyrrolidine amide derivative and application thereof. Specifically, the invention relates to a novel acyl-substituted pyrrolidine amide derivative and a pharmaceutical composition containing the compound, which can be used for activation of beta3-adrenoceptor. The invention also relates to a method for preparing the compound and the pharmaceutical composition and their application in the preparation of beta3-adrenoceptor activation-mediated diseases or symptoms, especially overactive bladder.