7-Fluoro-imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 7-Fluoro-imidazo[1,2-a]pyridine
• CAS No.: 1260903-17-0
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.13
• Hs Code.: 2933990090
• Mol file: 1260903-17-0.mol

Synonyms:7-Fluoro-imidazo[1,2-a]pyridine

Chemical Property of 7-Fluoro-imidazo[1,2-a]pyridine

Chemical Property:

• PKA: 5.74±0.50(Predicted)
• PSA: 17.30000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 1.47340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

7-Fluoroimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Fluoro-imidazo[1,2-a]pyridine

There total 3 articles about 7-Fluoro-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-fluoropyridin-2-amine (944401-77-8) + acetylene (74-86-2,25067-58-7) → 7-fluoroimidazolo[1,2-a]pyridine (1260903-17-0)

Guidance literature:

With sodium persulfate; C₂₂H₁₅CuN₄⁽¹⁺⁾*CF₃O₃S^(1-); In N,N-dimethyl acetamide; at 90 ℃; for 24h; under 1520.1 - 2280.15 Torr; Reagent/catalyst; Temperature; Solvent;

Reference yield: 82.35%

2-chloroethanal (107-20-0) + 4-fluoropyridin-2-amine (944401-77-8) → 7-fluoroimidazolo[1,2-a]pyridine (1260903-17-0)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; at 60 ℃; for 4h;

Reference yield:

C7H5FN2*C2H2O4*H2O → 7-fluoroimidazolo[1,2-a]pyridine (1260903-17-0)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 10 - 20 ℃; pH=9 - 10;

upstream raw materials:

4-fluoropyridin-2-amine

acetylene

2-chloroethanal

Downstream raw materials:

7-fluoro-3-bromoimidazo[1,2-a]pyridine

Refernces

• 1、 -. "Synthesis method of 7-fluoroimidazole[1, 2-a]pyridine promoted by copper complex". Paragraph 0017-0019; 0020-0022; 0023-0025; 0026-0028. . Retrieved 2020/09/16.