Technology Process of 3-Boc-9-oxa-3,7-diazabicyclo[3.3.1]nonane hydrochloride
There total 8 articles about 3-Boc-9-oxa-3,7-diazabicyclo[3.3.1]nonane hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
palladium;
In
methanol; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol / 3 h / 80 °C
2.1: methanesulfonic acid / toluene / 16 h / 110 °C
3.1: hydrogen bromide / water / 32 h / 105 °C
3.2: 1 h
4.1: sodium hydrogencarbonate / water; dichloromethane / 1.5 h / 20 °C
5.1: hydrogenchloride / ethyl acetate; diethyl ether / 1 h / -10 °C / Inert atmosphere
6.1: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 760.05 Torr / Inert atmosphere
With
hydrogenchloride; methanesulfonic acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium hydrogencarbonate;
In
methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / toluene / 16 h / 110 °C
2.1: hydrogen bromide / water / 32 h / 105 °C
2.2: 1 h
3.1: sodium hydrogencarbonate / water; dichloromethane / 1.5 h / 20 °C
4.1: hydrogenchloride / ethyl acetate; diethyl ether / 1 h / -10 °C / Inert atmosphere
5.1: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 760.05 Torr / Inert atmosphere
With
hydrogenchloride; methanesulfonic acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium hydrogencarbonate;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; toluene;
