Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride
• CAS No.: 41940-43-6
• Molecular Formula: C₈H₁₁NO₂S*ClH
• Molecular Weight: 221.708
• Hs Code.: 2934999090
• European Community (EC) Number: 963-586-5
• DSSTox Substance ID: DTXSID60598079
• Mol file: 41940-43-6.mol

Synonyms:41940-43-6;ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride;5-AMINO-3-METHYL-2-THIOPHENECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE;ethyl 5-amino-3-methylthiophene-2-carboxylate;hydrochloride;SCHEMBL244320;DTXSID60598079;ethyl 2-amino-4-methylthiophene-5-carboxylate hydrochloride;ZBGUERNJHMVQLZ-UHFFFAOYSA-N;AKOS005287439;DB-334089;EN300-30086;G31916;ethyl5-amino-3-methylthiophene-2-carboxylatehydrochloride;F8887-4827;Ethyl 5-amino-3-methylthiophene-2-carboxylate--hydrogen chloride (1/1)

Chemical Property of Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride

Chemical Property:

• PSA: 80.56000
• LogP: 3.19860
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 221.0277275
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

98%Min ^*data from raw suppliers

ethyl5-amino-3-methylthiophene-2-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(C=C(S1)N)C.Cl

Technology Process of Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride

There total 1 articles about Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-Amino-2-ethoxycarbonyl-3-methyl-thiophen-hydrochlorid (41940-43-6)

Guidance literature:

Gemisch cis-trans-3-Cyan-2-methylpropen-(2)-carbonsaeuremethylester, Schwefel / Ethanol, Diethylamin;

Reference yield: 98.0%

5-Amino-2-ethoxycarbonyl-3-methyl-thiophen-hydrochlorid (41940-43-6) → ethyl 5-amino-3-methylthiophene-2-carboxylate (88796-28-5)

Guidance literature:

With water; sodium hydrogencarbonate; In dichloromethane; for 0.25h; Product distribution / selectivity;

Reference yield: 58.0%

5-Amino-2-ethoxycarbonyl-3-methyl-thiophen-hydrochlorid (41940-43-6) + chloroacetyl chloride (79-04-9) → 5-[(2-Chloracetyl)-amino]-3-methyl-2-thiophencarbonsaeureethylester (285138-55-8)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 60 ℃; for 2h;

Downstream raw materials:

5-[(2-Chloracetyl)-amino]-3-methyl-2-thiophencarbonsaeureethylester

4-Acetyl-5-[(2-chloracetyl)amino]-3-methylthiophen-2-carbonsaeureethylester

ethyl 5-amino-3-methylthiophene-2-carboxylate

ethyl 3-methyl-5-(phenoxycarbonylamino)thiophene-2-carboxylate