(4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one
CAS No.:324741-99-3
Molecular Formula:C16H17NO4
Molecular Weight:287.315
Hs Code.:
Mol file:324741-99-3.mol

Synonyms:(4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one;(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylMethyl)-2-oxazolidinone

Suppliers and Price of (4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
500mg
$ 1230.00

TRC
(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
50mg
$ 155.00

Medical Isotopes, Inc.
(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
500 mg
$ 2120.00

Medical Isotopes, Inc.
(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
50 mg
$ 640.00

Total 7 raw suppliers

Chemical Property of (4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one

Chemical Property:

PSA：66.84000
LogP:1.45140
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one can be used in the synthesis of enantioselective synthesis of carbocyclic ribavirin, its analogs and other antiviral agents.

Technology Process of (4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one

There total 5 articles about (4R)-3-[((1S,2S)-2-Hydroxy-3-cyclopenten-1-yl)carbonyl]-4-(phenylMethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 324741-98-2
(R)-3-((2S,3S)-2-Allyl-3-hydroxy-pent-4-enoyl)-4-benzyl-oxazolidin-2-one

: 324741-99-3
(4R)-3-{[(1S,2S)-2-hydroxy-3-cyclopenten-1-yl]carbonyl}-4-(phenylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
DOI:10.1016/S0040-4039(00)01704-4

Reference yield: 94.0%

: 1297139-24-2
(4R)-3-[(2S,3S,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 324741-99-3
(4R)-3-{[(1S,2S)-2-hydroxy-3-cyclopenten-1-yl]carbonyl}-4-(phenylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: zhan catalyst lB; In toluene; at 20 ℃; Inert atmosphere;

Reference yield:

: 155399-10-3
(4R)-3-(4-pentenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 324741-99-3
(4R)-3-{[(1S,2S)-2-hydroxy-3-cyclopenten-1-yl]carbonyl}-4-(phenylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / n-Bu₂BOTf; iPr₂NEt / -78 °C

2: 96 percent / Grubb's catalyst

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
DOI:10.1016/S0040-4039(00)01704-4