1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Base Information

Chemical Name:1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone
CAS No.:1297139-34-4
Molecular Formula:C₂₂H₃₃N₃O₆SSi
Molecular Weight:495.672
Hs Code.:

Synonyms:1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Suppliers and Price of 1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

There total 8 articles about 1-((1S,2S,3S,5S)-2-{[(1,1-diMethylethyl)(diMethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297139-24-2
(4R)-3-[(2S,3S,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 1297139-34-4
1-((1S,2S,3S,5S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: zhan catalyst lB / toluene / 20 °C / Inert atmosphere

2.1: diethylzinc / dichloromethane; hexane / 0.33 h / 0 °C

2.2: 6.33 h / 0 - 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / toluene / 5 h / 80 °C

5.2: 1 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h

7.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; diphenyl phosphoryl azide; dihydrogen peroxide; diethylzinc; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zhan catalyst lB; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 324741-99-3
(4R)-3-{[(1S,2S)-2-hydroxy-3-cyclopenten-1-yl]carbonyl}-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 1297139-34-4
1-((1S,2S,3S,5S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylzinc / dichloromethane; hexane / 0.33 h / 0 °C

1.2: 6.33 h / 0 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 5 h / 80 °C

4.2: 1 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; diphenyl phosphoryl azide; dihydrogen peroxide; diethylzinc; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1297139-25-3
(4R)-3-{[(1S,2S,3S,5S)-2-hydroxybicyclo[3.1.0]hex-3-yl]carbonyl}-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 1297139-34-4
1-((1S,2S,3S,5S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}bicyclo[3.1.0]hex-3-yl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 5 h / 80 °C

3.2: 1 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; diphenyl phosphoryl azide; dihydrogen peroxide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;