2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID

Base Information

• Chemical Name: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID
• CAS No.: 90563-75-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176

Synonyms:2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID;2-(2-Pyridyl)cyclopropanecarboxylic Acid

Chemical Property of 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID

Chemical Property:

• PSA: 50.19000
• LogP: 1.26970
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(pyridin-2-yl)cyclopropanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID

There total 7 articles about 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-ethyl 2-(pyridin-2-yl)cyclopropanecarboxylate (4903-95-1,58620-63-6) → (±)-trans-2-(pyridin-2-yl)cyclopropanecarboxylic acid (90563-75-0)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01178a010

Reference yield:

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → (±)-trans-2-(pyridin-2-yl)cyclopropanecarboxylic acid (90563-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene / 120 - 130 °C

2: aq.-ethanolic KOH

With potassium hydroxide; xylene;

DOI:10.1021/ja01178a010

Reference yield:

ethyl 3-(pyridin-2-yl)acrylate (7340-23-0) → (±)-trans-2-(pyridin-2-yl)cyclopropanecarboxylic acid (90563-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / dimethyl sulfoxide / 50 °C

2: sodium hydroxide / methanol / 50 °C

With sodium hydride; sodium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2013.09.069

upstream raw materials:

cis-ethyl 2-(pyridin-2-yl)cyclopropanecarboxylate

2-vinylpyridine

trans-ethyl 2-(pyridin-2-yl)cyclopropanecarboxylate

ethyl 3-(pyridin-2-yl)acrylate

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