Technology Process of 2-bromo-5-fluoro-1,4-benzenedimethanol
There total 6 articles about 2-bromo-5-fluoro-1,4-benzenedimethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromo-2-fluoro-4-(hydroxymethyl)benzaldehyde;
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 0.166667h;
With
water;
In
methanol;
- Guidance literature:
-
2-bromo-5-fluorobenzyl alcohol;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium;
In
tetrahydrofuran; hexane;
at -40 ℃;
for 2h;
N,N-dimethyl-formamide;
at -78 - 20 ℃;
for 1h;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
for 2.5h;
DOI:10.1016/j.ejmech.2019.07.032
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - 40 °C
1.2: 0.5 h / -78 - 20 °C
2.1: sodium tetrahydroborate / methanol / 0.17 h / 0 °C
With
2,2,6,6-tetramethyl-piperidine; sodium tetrahydroborate; n-butyllithium;
In
tetrahydrofuran; methanol; hexane;
