CZC-54252

Base Information

• Chemical Name: CZC-54252
• CAS No.: 1191911-27-9
• Molecular Formula: C22H25ClN6O4S
• Molecular Weight: 504.997
• Mol file: 1191911-27-9.mol

Synonyms:CZC-54252;N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide;CZC 54252 hydrochloride

Chemical Property of CZC-54252

Chemical Property:

• Boiling Point: 718.1±70.0 °C(Predicted)
• PKA: 8.50±0.10(Predicted)
• PSA: 126.09000
• Density: 1.452±0.06 g/cm3(Predicted)
• LogP: 5.19870
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

CZC 54252 hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CZC 54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2 mutations are associated with familial Parkinson''s disease and a potential therapeutic target.

Technology Process of CZC-54252

There total 1 articles about CZC-54252 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

N4-(2-aminophenyl)-5-chloro-N2-(2-methoxy-4-morpholinophenyl)pyrimidin-2,4-diamine + methanesulfonyl chloride (124-63-0) → N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide (1191911-27-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

methanesulfonyl chloride

Refernces