MK-8742

Base Information

• Chemical Name: MK-8742
• CAS No.: 1444832-51-2
• Molecular Weight: 882.0171
• Mol file: 1444832-51-2.mol

Synonyms:MK-8742;Elbasvir intermediate

Chemical Property of MK-8742

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Elbasvir-d6 is a labelled version of Elbasvir (E501010), a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. Elbasvir Inhibits NS5A, an important viral phosphoprotein.

Technology Process of MK-8742

There total 47 articles about MK-8742 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole (1585969-27-2) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester (1370468-36-2,1444832-51-2)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 10 - 20 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1021/ol500971c

Reference yield: 82.0%

methyl ((S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (1292836-05-5) + (S)-6-phenyl-3,10-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo-[5,6][1,3]oxazino-[3,4-a]indole → N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester (1370468-36-2,1444832-51-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; potassium carbonate; In 1,2-dimethoxyethane; at 85 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jacs.5b05934

Reference yield: 30.0%

C35H33N7O*ClH (1585969-27-2) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester (1370468-36-2,1444832-51-2) + C49H55N9O7 (1370468-37-3,1444832-51-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1002/cmdc.201300343

upstream raw materials:

4'-bromo-2'-hydroxyacetophenone

C₃₅H₃₃N₇O

N-methoxycarbonyl-L-valine

L-valine