4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID

Base Information

Chemical Name:4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID
CAS No.:856893-66-8
Molecular Formula:C₁₀H₁₀N₂O₃
Molecular Weight:206.201
Hs Code.:

Synonyms:4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID;4-Methoxy-6-methyl-1H-indazole-3-carboxylic acid

Suppliers and Price of 4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID

Chemical Property:

PSA：75.21000
LogP:1.57810

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID

There total 8 articles about 4-METHOXY-6-METHYL-3-(1H)INDAZOLE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856893-65-7
1-amino-3,3,4-trimethoxy-6-methylindolin-2-one

: 856893-66-8
4-methoxy-6-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: With sulfuric acid; In water; at 20 - 85 ℃; for 4h;
DOI:10.1021/ol050769m

Reference yield:

: 856893-61-3
N-(3-methoxy-5-methylphenyl)-2,2-dimethylpropionamide

: 856893-66-8
4-methoxy-6-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: TMEDA; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: 48 percent / ethanol; hexane / 2.5 h / -78 - 20 °C

2.1: 99 percent / HCl / 1,2-dimethoxy-ethane / 5 h / Heating

3.1: 90 percent / p-TsOH*H₂O / methanol / 6 h / Heating

4.1: 91 percent / NaH; O-(diphenylphosphinyl)hydroxylamine / tetrahydrofuran / 0.75 h / 0 - 20 °C

5.1: H₂SO₄ / H₂O / 4 h / 20 - 85 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; O-(diphenylphosphinyl)hydroxylamine; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water;
DOI:10.1021/ol050769m

Reference yield:

: 856893-63-5
4-methoxy-6-methyl-1H-indole-2,3-dione

: 856893-66-8
4-methoxy-6-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / p-TsOH*H₂O / methanol / 6 h / Heating

2: 91 percent / NaH; O-(diphenylphosphinyl)hydroxylamine / tetrahydrofuran / 0.75 h / 0 - 20 °C

3: H₂SO₄ / H₂O / 4 h / 20 - 85 °C

With sulfuric acid; O-(diphenylphosphinyl)hydroxylamine; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water;
DOI:10.1021/ol050769m