DihydrochlaMydocin

Base Information

Chemical Name:DihydrochlaMydocin
CAS No.:157618-75-2
Molecular Formula:C28H40N4O6
Molecular Weight:528.649
Hs Code.:
Mol file:157618-75-2.mol

Synonyms:DihydrochlaMydocin;Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(2S,9R)-2-amino-9-hydroxy-8-oxodecanoyl]

Suppliers and Price of DihydrochlaMydocin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of DihydrochlaMydocin

Chemical Property:

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

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MSDS Files:

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Technology Process of DihydrochlaMydocin

There total 19 articles about DihydrochlaMydocin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1247053-01-5
(-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

: 157618-75-2
(-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h;

Reference yield: 63.0%

: 874384-22-2
(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

: 157618-75-2
(-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 4 - 20 ℃; for 2h;
DOI:10.1021/jo0518250

Reference yield:

: 850209-98-2
(S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester

: 157618-75-2
(-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:: Multi-step reaction with 8 steps

1.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.1: LiN(SiMe₃)2 / tetrahydrofuran / 0 °C

2.2: tetrahydrofuran / 12 h / 20 °C

3.1: 94 percent / HCl / ethyl acetate / 0.33 h / 20 °C

4.1: LiCl; ethyldiisopropylamine / acetonitrile / 72 h / 20 °C

5.1: 75 percent / H₂ / Pd(OH)2/C / methanol / 12 h / 20 °C / 4560 Torr

6.1: 60 percent / trifluoroacetic acid; H₂O; triisopropyl silane / 0.33 h

7.1: 63 percent / HATU; ethyldiisopropylamine / CH₂Cl₂ / 2 h / 4 - 20 °C

With hydrogenchloride; oxalyl dichloride; chlorotriisopropylsilane; water; hydrogen; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium chloride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile; 1.1: Swern oxidation / 4.1: Wittig-Horner-Emmons reaction;
DOI:10.1021/jo0518250