tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate
• CAS No.: 1186688-52-7
• Molecular Formula: C10H17F2NO3
• Molecular Weight: 237.247
• Mol file: 1186688-52-7.mol

Synonyms:tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate

Chemical Property of tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 1.56130

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl4,4-Difluoro-3-hydroxypiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate

There total 2 articles about tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.8%

di-tert-butyl dicarbonate (24424-99-5) + 4,4-difluoropiperidin-3-ol → 4,4-difluoro-3-hydroxy-1-piperidine carboxylic acid tert-butyl ester (1186688-52-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-(benzyloxy)-4,4-difluoro-1-piperidine carboxylic acid benzyl ester (1186688-50-5) → 4,4-difluoro-3-hydroxy-1-piperidine carboxylic acid tert-butyl ester (1186688-52-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; tert-butyl alcohol; at 60 ℃; for 12h; under 4654.46 Torr;

Reference yield: 87.5%

4,4-difluoro-3-hydroxy-1-piperidine carboxylic acid tert-butyl ester (1186688-52-7) + benzyl bromide (100-39-0) → C17H23F2NO3

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

3-(benzyloxy)-4,4-difluoro-1-piperidine carboxylic acid benzyl ester

Downstream raw materials:

4,4-difluoro-3-piperidinol hydrochloride

3-benzyloxy-4,4-difluoropiperidine

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