methyl 3-amino-6-methylpicolinate

Base Information

• Chemical Name: methyl 3-amino-6-methylpicolinate
• CAS No.: 1228188-32-6
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Mol file: 1228188-32-6.mol

Synonyms:methyl 3-amino-6-methylpicolinate;methyl 3-amino-6-methyl-2-pyridinecarboxylate

Chemical Property of methyl 3-amino-6-methylpicolinate

Chemical Property:

• PSA: 65.21000
• LogP: 1.34000

Purity/Quality:

95+% ^*data from raw suppliers

3-Amino-6-methyl-pyridine-2-carboxylicacidmethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-amino-6-methylpicolinate

There total 4 articles about methyl 3-amino-6-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-{[(tert-butoxy)carbonyl]amino}-6-methylpyridine-2-carboxylate (908831-88-9) → methyl 3-amino-6-methylpyridine-2-carboxylate (1228188-32-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

6-methylpyridine-2,3-dicarboxylic acid (53636-70-7) → methyl 3-amino-6-methylpyridine-2-carboxylate (1228188-32-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride / 5 h / 100 °C / Inert atmosphere

2.1: methanol / 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / toluene / 0.17 h / 20 °C

3.2: 1 h / Reflux

3.3: 1 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With methanol; acetic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

6-methylpyridine-2,3-dicarboxylic acid anhydride (90376-83-3) → methyl 3-amino-6-methylpyridine-2-carboxylate (1228188-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 3 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / toluene / 0.17 h / 20 °C

2.2: 1 h / Reflux

2.3: 1 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With methanol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;

upstream raw materials:

methyl 3-{[(tert-butoxy)carbonyl]amino}-6-methylpyridine-2-carboxylate

6-methylpyridine-2,3-dicarboxylic acid

6-methylpyridine-2,3-dicarboxylic acid anhydride

2-(methoxycarbonyl)-6-methylpyridine-3-carboxylic acid

Refernces

• 1、 -. "AZABICYCLO [4.1.0] HEPT - 4 - YL DERIVATIVES AS HUMAN OREXIN RECEPTOR ANTAGONISTS". Page/Page column 42. . Retrieved 2012/07/14.
• 2、 -. "5-METHYL-PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF SLEEP DISORDER". Page/Page column 27-28. . Retrieved 2011/04/14.