Dimethyl 6-methylpyridine-2,3-dicarboxylate

Base Information

• Chemical Name: Dimethyl 6-methylpyridine-2,3-dicarboxylate
• CAS No.: 135338-27-1
• Molecular Formula: C9H9NO4
• DSSTox Substance ID: DTXSID40537663
• Wikidata: Q82412727
• Mol file: 135338-27-1.mol

Synonyms:Dimethyl 6-methylpyridine-2,3-dicarboxylate;135338-27-1;SCHEMBL10665321;DTXSID40537663

Chemical Property of Dimethyl 6-methylpyridine-2,3-dicarboxylate

Chemical Property:

• Vapor Pressure: 0.00404mmHg at 25°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 209.06880783
• Heavy Atom Count: 15
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)C(=O)OC)C(=O)OC

Technology Process of Dimethyl 6-methylpyridine-2,3-dicarboxylate

There total 5 articles about Dimethyl 6-methylpyridine-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 6-methylpyridine-2,3-dicarboxylic acid anhydride (90376-83-3) → 2-(methoxycarbonyl)-6-methylpyridine-3-carboxylic acid (135338-27-1)

Guidance literature:

at 0 - 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2004.11.078

Reference yield:

6-methylpyridine-2,3-dicarboxylic acid anhydride (90376-83-3) → 2-(methoxycarbonyl)-6-methylpyridine-3-carboxylic acid (135338-27-1)

Guidance literature:

With methanol; at 0 - 20 ℃; for 3h;

Reference yield:

methanol (67-56-1) + 6-methylpyridine-2,3-dicarboxylic acid anhydride (90376-83-3) → 3-(methoxycarbonyl)-6-methylpyridine-2-carboxylic acid + 2-(methoxycarbonyl)-6-methylpyridine-3-carboxylic acid (135338-27-1)

Guidance literature:

In tetrahydrofuran; at 80 ℃; regioselective reaction;

DOI:10.1016/j.tetlet.2013.10.020

upstream raw materials:

methanol

6-methylpyridine-2,3-dicarboxylic acid anhydride

6-methylpyridine-2,3-dicarboxylic acid

Downstream raw materials:

methyl 3-amino-6-methylpyridine-2-carboxylate