3-Nitro-6-(trifluoromethyl)pyridin-2-amine

Base Information

• Chemical Name: 3-Nitro-6-(trifluoromethyl)pyridin-2-amine
• CAS No.: 893444-21-8
• Molecular Formula: C₆H₄F₃N₃O₂
• Molecular Weight: 207.112
• DSSTox Substance ID: DTXSID60695310
• Wikidata: Q82624462
• Mol file: 893444-21-8.mol

Synonyms:3-NITRO-6-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;893444-21-8;2-Amino-3-nitro-6-(trifluoromethyl)pyridine;SCHEMBL898028;DTXSID60695310;YSMYCFONKCAXBB-UHFFFAOYSA-N;MFCD11847683;AKOS016005749;AB64720;DS-15848;C77006;A861234

Chemical Property of 3-Nitro-6-(trifluoromethyl)pyridin-2-amine

Chemical Property:

• PSA: 84.73000
• LogP: 2.69520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 0
• Exact Mass: 207.02556087
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

97% ^*data from raw suppliers

3-Nitro-6-(trifluoromethyl)pyridin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1[N+](=O)[O-])N)C(F)(F)F

Technology Process of 3-Nitro-6-(trifluoromethyl)pyridin-2-amine

There total 2 articles about 3-Nitro-6-(trifluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3-nitro-6-(trifluoromethyl)pyridine (117519-08-1) → 3-nitro-6-(trifluoromethyl)pyridin-2-amine (893444-21-8)

Guidance literature:

With ammonia; In ethanol; at 20 ℃; for 15h;

Reference yield:

2-amino-6-(trifluoromethyl)pyridine (34486-24-3) → 3-nitro-6-(trifluoromethyl)pyridin-2-amine (893444-21-8)

Guidance literature:

With sulfuric acid; potassium nitrate; at 20 ℃; for 2h;

Reference yield: 100.0%

3-nitro-6-(trifluoromethyl)pyridin-2-amine (893444-21-8) → 6-(trifluoromethyl) pyridine-2,3-diamine (683242-79-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 1.5h;

upstream raw materials:

2-chloro-3-nitro-6-(trifluoromethyl)pyridine

2-amino-6-(trifluoromethyl)pyridine

Downstream raw materials:

6-(trifluoromethyl) pyridine-2,3-diamine

C₂HF₃O₂*C₂₆H₂₄F₄N₆O₂

C₂₄H₁₉F₄N₆O₂^(1-)*Na⁽¹⁺⁾