117519-08-1

Basic information

• Product Name: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine
• Synonyms: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine;2-cloro-3-nitro-6-(trifluoromethyl) pyridine;2-Chloro-6-(trifluoromethyl)-3-nitropyridine;Pyridine,2-chloro-3-nitro-6-(trifluoromethyl)-
• CAS NO: 117519-08-1
• Molecular Formula: C₆H₂ClF₃N₂O₂
• Molecular Weight: 226.5404896
• Product Categories: Fluorine series
• Mol File: 117519-08-1.mol

Chemical Properties

• Boiling Point: 242℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.618
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -7.04±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(117519-08-1)
• EPA Substance Registry System: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(117519-08-1)

Safety Data

• Hazardous Substances Data: 117519-08-1(Hazardous Substances Data)

Usage

Uses

2-Chloro-3-nitro-6-(trifluoromethyl)pyridine

InChI:InChI=1/C6H2ClF3N2O2/c7-5-3(12(13)14)1-2-4(11-5)6(8,9)10/h1-2H

Upstream product

• 34486-06-1 2-hydroxy-6-trifluoromethylpyridine 
• 117519-09-2 3-amino-2-chloro-6-(trifluoromethyl)pyridine 
• 10026-13-8 phosphorus pentachloride 
• 117519-07-0 3-nitro-6-(trifluoromethyl)pyridin-2-ol 

Downstream Products

• 617678-31-6 N-benzyl-N-(3-nitro-6-trifluoromethylpyridin-2-yl)amine 
• 893444-21-8 3-nitro-6-(trifluoromethyl)pyridin-2-amine 
• 1340544-30-0 C₁₂H₅F₅N₂O₃ 
• 163317-99-5 C₁₂H₇F₅N₂O 
• 163318-02-3 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]methanesulfonamide 
• 163318-00-1 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]ethanesulfonamide 
• 1340544-33-3 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide 
• 1355342-87-8 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide 

Relevant articles and documents

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

PESTICIDAL 3-(ARYLOXY)AZACYCLOALKANES

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A1 is N or CR7; A2 is N or CR8;A3 is N or CR9; A4 is N or CR10; provided that not more than two of A1, A2, A3 and A4 are N; T is O, S(O)k or NR36; L is -C(R11)=C(R12)-, wherein the carbon atom bonded to R11 is also bonded to CR4R5 and the carbon atom bonded to R12 is also bonded to R6; or 1,4-diphenylene optionally substituted with up to 4 substituents independently selected from R13; or C(R34)(R35)-Z-, wherein the carbon atom bonded to R34 and R35 is also bonded to CR4R5 and Z is bonded to R6; Z is O, S(O)m, NR37 or CR38R39; R1 is a phenyl or 5- or 6-membered heteroaromatic ring optionally substituted with up to 5 substituents independently selected from R14; R6 is a phenyl or 5- or 6-membered heteroaromatic ring optionally substituted with up to 5 substituents independently selected from R22; s is 1, 2 or 3; t is 1 or 2; provided that the sum of s and t is 2, 3 or 4; and R2, R3, R4, R5, R7, R8, R9, R10, R11, R12, R13, R14, R22, R34, R35, R36, R37, R38, R39, W, k, m and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Synthesis of substituted azaoxindoles for the preparation of aza-tenidap analogs

The preparation of a set of eight azaoxindoles bearing substituents on the aromatic nucleus is outlined. These compounds were required for the preparation of aza-analogs of the anti-inflammatory oxindole tenidap. Two methods of synthesis were used, the fi