117519-08-1

Basic information

• Product Name: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine
• Synonyms: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine;2-cloro-3-nitro-6-(trifluoromethyl) pyridine;2-Chloro-6-(trifluoromethyl)-3-nitropyridine;Pyridine,2-chloro-3-nitro-6-(trifluoromethyl)-
• CAS NO: 117519-08-1
• Molecular Formula: C₆H₂ClF₃N₂O₂
• Molecular Weight: 226.5404896
• Product Categories: Fluorine series
• Mol File: 117519-08-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 242℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.618
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -7.04±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(117519-08-1)
• EPA Substance Registry System: 2-Chloro-3-Nitro-6-Trifluoromethyl Pyridine(117519-08-1)

Safety Data

• Hazardous Substances Data: 117519-08-1(Hazardous Substances Data)

Usage

Uses

2-Chloro-3-nitro-6-(trifluoromethyl)pyridine

InChI:InChI=1/C6H2ClF3N2O2/c7-5-3(12(13)14)1-2-4(11-5)6(8,9)10/h1-2H

Upstream product

• 34486-06-1 2-hydroxy-6-trifluoromethylpyridine 
• 10026-13-8 phosphorus pentachloride 
• 117519-07-0 3-nitro-6-(trifluoromethyl)pyridin-2-ol 
• 117519-09-2 3-amino-2-chloro-6-(trifluoromethyl)pyridine 

Downstream Products

• 1355342-87-8 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide 
• 1340544-33-3 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide 
• 163318-00-1 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]ethanesulfonamide 
• 163318-02-3 N-[2-(2,4-difluorophenoxy)-6-trifluoromethyl-3-pyridyl]methanesulfonamide 
• 163317-99-5 C₁₂H₇F₅N₂O 
• 1340544-30-0 C₁₂H₅F₅N₂O₃ 
• 893444-21-8 3-nitro-6-(trifluoromethyl)pyridin-2-amine 
• 617678-31-6 N-benzyl-N-(3-nitro-6-trifluoromethylpyridin-2-yl)amine 

Relevant articles and documents

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.