2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride
• CAS No.: 1341200-77-8
• Molecular Formula: C₁₀H₅Cl₃FN₃O₂S
• Molecular Weight: 0
• Mol file: 1341200-77-8.mol

Synonyms:2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride

Chemical Property of 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride

Chemical Property:

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Technology Process of 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride

There total 2 articles about 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2,5-dichloro-N-(4-fluorophenyl)pyrimidine-4-amine (280582-13-0) → 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride (1341200-77-8)

Guidance literature:

With chlorosulfonic acid; for 4h;

DOI:10.1021/ml200198x

Reference yield:

4-fluoroaniline (371-40-4) → 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride (1341200-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / Reflux

2: chlorosulfonic acid / 4 h

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;

DOI:10.1021/ml200198x

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + 2-((2,5-dichloropyrimidin-4-yl)amino)-5-fluorobenzene-1-sulfonyl chloride (1341200-77-8) → 2,5-dichloro-N-(4-fluoro-2-(morpholinosulfonyl)phenyl)pyrimidin-4-amine (1341200-78-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ml200198x

upstream raw materials:

2,5-dichloro-N-(4-fluorophenyl)pyrimidine-4-amine

4-fluoroaniline

Downstream raw materials:

2,5-dichloro-N-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidin-4-amine

2,5-dichloro-N-(4-fluoro-2-(morpholinosulfonyl)phenyl)pyrimidin-4-amine

5-chloro-N₄-(4-fluoro-2-(morpholinosulfonyl)phenyl)-N₂-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidine-2,4-diamine

5-chloro-N₄-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N₂-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidine-2,4-diamine

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