4-methoxy-3-methylbenzonitrile

Base Information

• Chemical Name: 4-methoxy-3-methylbenzonitrile
• CAS No.: 53078-71-0
• Molecular Formula: C9H9NO
• Molecular Weight: 147.177
• Hs Code.: 2926907090
• Mol file: 53078-71-0.mol

Synonyms:4-methoxy-3-methylbenzonitrile

Chemical Property of 4-methoxy-3-methylbenzonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 1.87528
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Methoxy-3-methylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-3-methylbenzonitrile

There total 14 articles about 4-methoxy-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-methyl-3-thiocyanato-1H-indole (31418-19-6) + 4-methoxy-3-methylphenylboronic acid (175883-62-2) → 4-methoxy-3-methylbenzonitrile (53078-71-0)

Guidance literature:

With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water; for 2h;

DOI:10.1080/17415993.2018.1469632

Reference yield: 90.0%

4-thiocyanatoaniline (2987-46-4) + 4-methoxy-3-methylphenylboronic acid (175883-62-2) → 4-methoxy-3-methylbenzonitrile (53078-71-0)

Guidance literature:

With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water; at 20 ℃; for 2h; Solvent; Temperature;

DOI:10.1080/17415993.2018.1469632

Reference yield: 88.0%

2-methylmethoxybenzene (578-58-5) + acetonitrile (75-05-8,26809-02-9) → 4-methoxy-3-methylbenzonitrile (53078-71-0)

Guidance literature:

2-methylmethoxybenzene; With N-iodo-succinimide; oxygen; ytterbium(III) triflate; In acetonitrile; at 150 ℃; for 0.5h;

acetonitrile; With 2,2,6,6-tetramethyl-piperidine-N-oxyl; 1,10-Phenanthroline; copper(II) nitrate trihydrate; 1,1,1,2,2,2-hexamethyldisilane; oxygen; at 150 ℃; for 60h;

DOI:10.1021/acs.orglett.5b00886

upstream raw materials:

β-4-methoxy-3-methyl-benzaldehyde-oxime

acetic anhydride

4-methoxy-3-methyl-benzaldehyde seqtrans-oxime

3-methyl-4-(methyloxy)benzaldehyde oxime

Downstream raw materials:

4-methoxy-3-methylbenzoic acid

3-bromomethyl-4-methoxybenzonitrile

(3-bromophenyl)(4-methoxy-3-methylphenyl)methanimine

4-hydroxy-3-methylbenzonitrile

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