Technology Process of 8-Amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester
There total 1 articles about 8-Amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Aus Ethyl-7-acetoxy-8-nitro-4-oxo-4H-chromen-2-carboxylat, H2;
DOI:10.1039/j39700002518
- Guidance literature:
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Multi-step reaction with 5 steps
1: 92 percent / NaHCO3 / acetone / 2 h / 20 °C
2: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating
3: 93 percent / 4 h / 140 °C
4: 66 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 20 °C
5: 59 percent / p-TsOH*H2O / CH2Cl2 / 20 h / 20 °C
With
ethyl phosphate; 4 A molecular sieve; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetone;
1: chloroacetylation / 2: Cyclization / 3: Substitution / 4: Condensation / 5: Hydrolysis;
- Guidance literature:
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Multi-step reaction with 5 steps
1: 92 percent / NaHCO3 / acetone / 2 h / 20 °C
2: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating
3: 93 percent / 4 h / 140 °C
4: 60 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 20 °C
5: 60 percent / HCl (20 percent) / ethanol; tetrahydrofuran
With
hydrogenchloride; ethyl phosphate; 4 A molecular sieve; sodium hydride; sodium hydrogencarbonate;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetone;
1: chloroacetylation / 2: Cyclization / 3: Substitution / 4: Condensation / 5: Hydrolysis;
