2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

Base Information

Chemical Name:2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile
CAS No.:173033-37-9
Molecular Formula:C₂₄H₁₈N₂O₆
Molecular Weight:430.417
Hs Code.:

Synonyms:2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

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Chemical Property of 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

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Technology Process of 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

There total 6 articles about 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 173033-36-8
2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxamide

: 173033-37-9
2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

Guidance literature:: With trifluoroacetic anhydride; In pyridine; dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 30192-51-9
ethyl 8-amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylate

: 173033-37-9
2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / NaHCO₃ / acetone / 2 h / 20 °C

2: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating

3: 93 percent / 4 h / 140 °C

4: 83 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 17 h / 20 °C

5: 72 percent / 25 percent aq.NH₄OH / CH₂Cl₂; methanol / 96 h / 20 °C

6: 69 percent / (CF₃CO)2O / CH₂Cl₂; pyridine / 1.5 h / 20 °C

With ammonium hydroxide; ethyl phosphate; 4 A molecular sieve; sodium hydride; sodium hydrogencarbonate; trifluoroacetic anhydride; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1,2-dichloro-ethane; acetone; 1: chloroacetylation / 2: Cyclization / 3: Substitution / 4: Condensation / 5: ammonolysis / 6: Dehydration;

Reference yield:

: 32278-24-3
ethyl 8-N-(chloroacetyl)amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylate

: 173033-37-9
2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating

2: 93 percent / 4 h / 140 °C

3: 83 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 17 h / 20 °C

4: 72 percent / 25 percent aq.NH₄OH / CH₂Cl₂; methanol / 96 h / 20 °C

5: 69 percent / (CF₃CO)2O / CH₂Cl₂; pyridine / 1.5 h / 20 °C

With ammonium hydroxide; ethyl phosphate; 4 A molecular sieve; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1,2-dichloro-ethane; 1: Cyclization / 2: Substitution / 3: Condensation / 4: ammonolysis / 5: Dehydration;