(1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)

Base Information

Chemical Name:(1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)
CAS No.:905454-52-6
Molecular Formula:C18H19FO5S
Molecular Weight:366.41
Hs Code.:
Mol file:905454-52-6.mol

Synonyms:(1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)

Suppliers and Price of (1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1’S,2R)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane
250mg
$ 1320.00

Medical Isotopes, Inc.
(1??S,2R)-2-(2??-Tosyl-1??,2??-dihydroxyethyl)-6-fluorochromane
500 mg
$ 2200.00

Total 0 raw suppliers

Chemical Property of (1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)

Chemical Property:

PSA：81.21000
LogP:3.67490

Purity/Quality:: (1’S,2R)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)

There total 3 articles about (1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 303176-43-4
1-[6-fluoro-(2R)-3,4-dihydro-2H-benzopyran-2-yl]-(1S)-1,2-ethylene glycol

: 905454-52-6
(R,S)-(-)-α-[(p-toluenesulfonyloxy)methyl](6-fluoro-2-chromanyl)methanol

Guidance literature:: With pyridine; In dichloromethane;

Reference yield:

: 797054-25-2
1-[6-fluoro-(2R)-3,4-dihydro-2H-1-benzopyran-4-one]-(1S)-1,2-ethylene glycol

: 905454-52-6
(R,S)-(-)-α-[(p-toluenesulfonyloxy)methyl](6-fluoro-2-chromanyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; triethylsilane

2: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; triethylsilane; trifluoroacetic acid; In dichloromethane;