303176-43-4

Basic information

• Product Name: (1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane
• Synonyms: (1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane;(1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol
• CAS NO: 303176-43-4
• Molecular Formula: C₁₁H₁₃FO₃
• Molecular Weight: 212.2175232
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 303176-43-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 384.764°C at 760 mmHg
• Flash Point: 175.632°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• Solubility: Ethyl Acetate, Methanol,
• PKA: 14.25±0.20(Predicted)
• CAS DataBase Reference: (1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane(CAS DataBase Reference)
• NIST Chemistry Reference: (1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane(303176-43-4)
• EPA Substance Registry System: (1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane(303176-43-4)

Safety Data

• Hazardous Substances Data: 303176-43-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(-)-Nebivolol intermediate.

InChI:InChI=1/C11H13FO3/c12-8-2-4-10-7(5-8)1-3-11(15-10)9(14)6-13/h2,4-5,9,11,13-14H,1,3,6H2/t9-,11+/m0/s1

Upstream product

• 371-41-5 4-Fluorophenol 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 129050-26-6 (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene 
• 1030385-06-8 6-fluoro-3,4-dihydro-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2H-chromene 
• 197706-48-2 (2R)-6-fluoro-2-vinylchroman 
• 797054-25-2 1-[6-fluoro-(2R)-3,4-dihydro-2H-1-benzopyran-4-one]-(1S)-1,2-ethylene glycol 
• 905454-51-5 C₁₄H₁₇FO₃ 
• 303176-35-4 3-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-1-propanol 
• 783332-57-0 3-(2-((tert-butyldimethylsilyl)oxy)-5-fluorophenyl)propanal 
• 303176-34-3 2-alllyl-1-(tert-butyldimethylsilyloxy)-4-fluoro-benzene 
• 13997-72-3 1-allyl-2-hydroxy-5-fluorobenzene 
• 13990-72-2 1-allyloxy-4-fluorobenzene 
• 303176-38-7 5-(5-fluoro-2-hydroxy-phenyl)-E-2-penten-1-ol 
• 1345202-52-9 (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl acetate 

Downstream Products

• 197706-50-6 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran 
• 303176-45-6 1-[6-fluoro-(2R)-3,4-dihydro-2H-benzopyran-2-yl]-(1R)-1,2-ethylene glycol 
• 303176-46-7 (R)-2-[(R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate 
• 152520-56-4 nebivolol hydrochloride 
• 1199945-26-0 2-{benzyl-[2-(6-fluoro-chroman-2-yl)-2-hydroxy-ethyl]-amino}-1-(6-fluoro-chroman-2-yl)-ethanol 
• 1345202-60-9 (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate 
• 129050-26-6 (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene 
• 905454-52-6 (R,S)-(-)-α-[(p-toluenesulfonyloxy)methyl](6-fluoro-2-chromanyl)methanol 
• 303176-44-5 2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene 

Relevant articles and documents

Synthesis of intermediate compound and [...] (by machine translation)

Synthesis of intermediate compounds [a] and [...]. [Solution] a [...], asymmetric epoxidation, sulfonyl halide in the presence of base catalyst by sulfonation, alkylation of amines, such as synthesized by a series of cross-coupling reaction. [Effect] [...] important from the viewpoint of pharmacological value, high efficiency, low cost, and which meets the requirements of industrial, optical isomers may be prepared [...] and develop a method, which is very economical in social benefit. [Drawing] no (by machine translation)

Nebivolol synthetic method and intermediate compounds of the

The present invention relates to a synthesis method and an intermediate compound of nebivolol. Specifically the invention relates to the method for synthesizing the nebivolol, the intermediate compound of the nebivolol, and a method for preparing the intermediate compound.

PROCESS FOR THE CONVERSION OF (2R)-6-FLUORO-2-[(2S)-OXIRAN-2-YL]-3,4-DIHYDRO-2H-CHROMENE TO (2R)-6-FLUORO-2-[(2R)-OXIRAN-2-YL]-3,4-DIHYDRO-2H-CHROMENE

The present invention relates to a novel process for the conversion of (2R)-6-fluoro- 2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene (formula lll-A) to (2R)-6-fluoro-2-[(2R)-oxiran- 2-yl]-3,4-dihydro-2H-chromene (formula lll-B). The compound of formula lll-