5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester
• CAS No.: 1052647-19-4
• Molecular Formula: C₁₄H₁₄ClN₃O₃
• Molecular Weight: 307.736
• Mol file: 1052647-19-4.mol

Synonyms:5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester

Chemical Property of 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester

There total 1 articles about 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-4,6-dichloropyrimidine (56-05-3) + methyl 2-methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1052647-21-8) → 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester (1052647-19-4)

Guidance literature:

With sodium hydrogencarbonate; palladium diacetate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 80 ℃;

Reference yield:

3-mercaptophenol (40248-84-8) + 5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester (1052647-19-4) → 5-[2-amino-6-(3-hydroxyphenylsulfanyl)pyrimidin-4-yl]-2-methoxy-4-methylbenzoic acid methyl ester (1052649-20-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 24h;

Reference yield:

5-(2-amino-6-chloropyrimidin-4-yl)-2-methoxy-4-methylbenzoic acid methyl ester (1052647-19-4) + 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol (67385-09-5) → 5-[2-amino-6-(2-tert-butoxycarbonylaminoethylsulfanyl)pyrimidin-4-yl]-2-methoxy-4-methylbenzoic acid methyl ester (1052648-19-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 15h;

upstream raw materials:

2-Amino-4,6-dichloropyrimidine

methyl 2-methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Downstream raw materials:

5-[2-amino-6-(2-tert-butoxycarbonylaminoethylsulfanyl)pyrimidin-4-yl]-2-methoxy-4-methylbenzoic acid methyl ester

5-[2-amino-6-(3-hydroxyphenylsulfanyl)pyrimidin-4-yl]-2-methoxy-4-methylbenzoic acid methyl ester

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