4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.:936368-55-7
Molecular Formula:C₁₅H₂₂N₄O₄
Molecular Weight:322.364
Hs Code.:
Mol file:936368-55-7.mol

Synonyms:4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Suppliers and Price of 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 496.83

Acrotein
1-Boc-4-(6-methyl-5-nitro-2-pyridinyl)-piperazine 97%
0.25g
$ 91.66

ACHEMBLOCK
1-Boc-4-(6-methyl-5-nitro-2-pyridinyl)-piperazine 95%
1G
$ 210.00

ACHEMBLOCK
1-Boc-4-(6-methyl-5-nitro-2-pyridinyl)-piperazine 95%
250MG
$ 110.00

Total 2 raw suppliers

Chemical Property of 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Boiling Point:480.2±45.0 °C(Predicted)
PKA:5.10±0.29(Predicted)
PSA：91.49000
Density:1.233±0.06 g/cm3(Predicted)
LogP:2.88140

Purity/Quality:

99% ^*data from raw suppliers

4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

There total 1 articles about 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 22280-60-0
6-chloro-4-methyl-3-nitropyridine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 936368-55-7
4-(6-methyl-5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In butan-1-ol; at 20 - 65 ℃;

Reference yield: 99.0%

: 936368-55-7
4-(6-methyl-5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 936368-54-6
4-(5-amino-6-methyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; 5% palladium over charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 17h; under 2068.65 - 2327.23 Torr;

Reference yield:

: 936368-55-7
4-(6-methyl-5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1392429-95-6
C₂₅H₃₁F₂N₅O₄S

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 48 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 3102.97 Torr / Autoclave

3: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 16 h / 120 °C / Inert atmosphere

With potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; hydrogen; copper(l) iodide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; toluene; 3: Ullmann Reaction;