3-bromo-5-(piperidin-1-ylmethyl)pyridine

Base Information

• Chemical Name: 3-bromo-5-(piperidin-1-ylmethyl)pyridine
• CAS No.: 866327-70-0
• Molecular Formula: C₁₁H₁₅BrN₂
• Molecular Weight: 255.157
• Hs Code.: 2933990090
• Mol file: 866327-70-0.mol

Synonyms:3-bromo-5-(piperidin-1-ylmethyl)pyridine;3-Bromo-5-(1-piperidinylmethyl)pyridine

Chemical Property of 3-bromo-5-(piperidin-1-ylmethyl)pyridine

Chemical Property:

• PSA: 16.13000
• LogP: 2.76790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-(piperidin-1-ylmethyl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromo-5-(piperidin-1-ylmethyl)pyridine

There total 2 articles about 3-bromo-5-(piperidin-1-ylmethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 3-bromo-5-(piperidin-1-ylmethyl)pyridine (866327-70-0)

Guidance literature:

With triethylamine; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; at 20 ℃;

Reference yield: 71.0%

piperidine (110-89-4) + 5-bromopyridine-3-carbaldehyde (113118-81-3) → 3-bromo-5-(piperidin-1-ylmethyl)pyridine (866327-70-0)

Guidance literature:

piperidine; 5-bromopyridine-3-carbaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

With sodium hydroxide; In dichloromethane; water; for 1h;

Reference yield:

2-methyl-4-(4-methylsulfanyl-phenyl)-1,2,3,4-tetrahydro-isoquinolin-7-ol (892408-41-2) + 3-bromo-5-(piperidin-1-ylmethyl)pyridine (866327-70-0) → 2-methyl-4-[4-(methylsulfanyl)phenyl]-7-[5-(piperidin-1-ylmethyl)-pyridin-3-yloxy]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; for 2h; Heating;

DOI:10.1016/j.bmcl.2007.08.017

upstream raw materials:

piperidine

5-bromopyridine-3-carbaldehyde

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