892408-41-2Relevant academic research and scientific papers
DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS
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Page/Page column 29, (2009/01/20)
Certain diaryl-substituted tetrahydroisoquinoline compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
Dual serotonin transporter inhibitor/histamine H3 antagonists: Development of rigidified H3 pharmacophores
Keith, John M.,Barbier, Ann J.,Wilson, Sandy J.,Miller, Kirstin,Boggs, Jamin D.,Fraser, Ian C.,Mazur, Curt,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 5325 - 5329 (2008/03/18)
A series of tetrahydroisoquinolines acting as dual serotonin transporter inhibitor/histamine H3 antagonists is described. The introduction of polar aromatic spacers as part of the histamine H3 pharmacophore was explored. A convergent synthesis of the final products allowing late stage introduction of the aromatic side chain was developed. In vitro and in vivo data are discussed.
TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS
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Page/Page column 175, (2010/11/08)
Certain tetrahydroisoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor-and serotonin-mediated diseases.
