Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate

Base Information

• Chemical Name: Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate
• CAS No.: 1381944-43-9
• Molecular Formula: C₁₂H₁₄N₂O₆
• Molecular Weight: 282.253
• Hs Code.: 2922509090
• Mol file: 1381944-43-9.mol

Synonyms:Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate;Methyl 4-((2-ethoxy-2-oxoethyl)-amino)-3-nitrobenzoate

Chemical Property of Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate

Chemical Property:

• PSA: 110.45000
• LogP: 1.95260
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl4-[(ethoxycarbonylmethyl)amino]-3-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate

There total 2 articles about Methyl 4-[(ethoxycarbonylMethyl)aMino]-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

methyl 4-amino-3-nitrobenzoate (3987-92-6) + ethyl bromoacetate (105-36-2) → methyl 3-nitro-4-((2-ethoxy-2-oxoethyl) amino)benzoate (1381944-43-9)

Guidance literature:

With caesium carbonate; at 140 ℃; for 20h;

Reference yield:

4-amino-3-nitrobenzoic acid (1588-83-6) → methyl 3-nitro-4-((2-ethoxy-2-oxoethyl) amino)benzoate (1381944-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4.5 h / 0 - 50 °C

2: caesium carbonate / 20 h / 140 °C

With thionyl chloride; caesium carbonate;

Reference yield:

methyl 3-nitro-4-((2-ethoxy-2-oxoethyl) amino)benzoate (1381944-43-9) → 1-(3,4-dimethoxybenzoyl)-3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 20 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2017.08.018

upstream raw materials:

methyl 4-amino-3-nitrobenzoate

ethyl bromoacetate

4-amino-3-nitrobenzoic acid

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