5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

Base Information

Chemical Name:5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester
CAS No.:294174-66-6
Molecular Formula:C15H17Cl2NO3
Molecular Weight:330.20638
Hs Code.:
Mol file:294174-66-6.mol

Synonyms:5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester;2-Benzofurancarboxylic acid, 5-[bis(2-chloroethyl)aMino]-, ethyl ester

Suppliers and Price of 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
2-Benzofurancarboxylicacid,5-[bis(2-chloroethyl)amino]-,ethylester
100mg
$ 97.00

Total 9 raw suppliers

Chemical Property of 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

Chemical Property:

PSA：42.68000
Density:1.297±0.06 g/cm3 (20 ºC 760 Torr)
LogP:3.89350

Purity/Quality:

97% ^*data from raw suppliers

2-Benzofurancarboxylicacid,5-[bis(2-chloroethyl)amino]-,ethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

There total 3 articles about 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69604-00-8
ethyl 5-nitrobenzo[d]furan-2-carboxylate

: 294174-66-6
5-[bis-(2-chloro-ethyl)-amino]-benzofuran-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / methanol; dioxane / 6 h / 3102.89 Torr

2: methanol / -10 - 20 °C

3: POCl₃ / 1 h / 100 °C

With hydrogen; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; 1: Catalytic hydrogenation / 2: Alkylation / 3: Chlorination;
DOI:10.1021/jm9911229

Reference yield:

: 294174-64-4
5-[bis-(2-hydroxy-ethyl)-amino]-benzofuran-2-carboxylic acid ethyl ester

: 294174-66-6
5-[bis-(2-chloro-ethyl)-amino]-benzofuran-2-carboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; at 100 ℃; for 1h;
DOI:10.1021/jm9911229

Reference yield:

: 174775-48-5
ethyl 5-amino-1-benzofuran-2-carboxylate

: 294174-66-6
5-[bis-(2-chloro-ethyl)-amino]-benzofuran-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / -10 - 20 °C

2: POCl₃ / 1 h / 100 °C

With trichlorophosphate; In methanol; 1: Alkylation / 2: Chlorination;
DOI:10.1021/jm9911229