3-(2,2,2-TRIFLUOROETHYL)PYRIDINE

Base Information

• Chemical Name: 3-(2,2,2-TRIFLUOROETHYL)PYRIDINE
• CAS No.: 1099598-09-0
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.127
• Hs Code.: 2933399090
• Mol file: 1099598-09-0.mol

Synonyms:3-(2,2,2-TRIFLUOROETHYL)PYRIDINE

Chemical Property of 3-(2,2,2-TRIFLUOROETHYL)PYRIDINE

Chemical Property:

• PSA: 12.89000
• LogP: 2.18640

Purity/Quality:

97% ^*data from raw suppliers

3-(2,2,2-Trifluoroethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(2,2,2-Trifluoroethyl)pyridine can be used as inhibitors of aldehyde dehydrogenases, especially, ALDH1a3 for therapeutic uses.

Technology Process of 3-(2,2,2-TRIFLUOROETHYL)PYRIDINE

There total 7 articles about 3-(2,2,2-TRIFLUOROETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Togni's reagent II (887144-94-7) + hydrazone of pyridine-3-carboxaldehyde (26364-02-3) → 3-(2,2,2-trifluoroethyl)pyridine (1099598-09-0)

Guidance literature:

With cesium fluoride; potassium hydroxide; In water; acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/chem.201902818

Reference yield:

[2,2,2-trifluoro-1-(3-pyridyl)ethyl] 4-methylbenzenesulfonate → 3-(2,2,2-trifluoroethyl)pyridine (1099598-09-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 12h; under 2585.81 Torr;

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 3-(2,2,2-trifluoroethyl)pyridine (1099598-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / 20 °C / Inert atmosphere

2: cesium fluoride; potassium hydroxide / acetonitrile; water / 0.17 h / 20 °C / Inert atmosphere

With hydrazine hydrate; cesium fluoride; potassium hydroxide; In ethanol; water; acetonitrile;

DOI:10.1002/chem.201902818

upstream raw materials:

1,1,1-trifluoro-2-iodoethane

3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Togni's reagent

3-pyridineacetic acid hydrochloride