2-Chloro-4-(4-methoxyphenylamino)pyrimidine

Base Information

• Chemical Name: 2-Chloro-4-(4-methoxyphenylamino)pyrimidine
• CAS No.: 191729-02-9
• Molecular Formula: C11H10ClN3O
• Molecular Weight: 235.673
• Mol file: 191729-02-9.mol

Synonyms:2-Chloro-4-(4-methoxyphenylamino)pyrimidine;2-Chloro-N-(4-methoxyphenyl)pyrimidin-4-amine

Chemical Property of 2-Chloro-4-(4-methoxyphenylamino)pyrimidine

Chemical Property:

• Vapor Pressure: 7.8E-08mmHg at 25°C
• Boiling Point: 436.9°C at 760 mmHg
• Flash Point: 218°C
• PSA: 47.04000
• Density: 1.324g/cm³
• LogP: 2.95520

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(4-methoxyphenyl)pyrimidin-4-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-(4-methoxyphenylamino)pyrimidine

There total 2 articles about 2-Chloro-4-(4-methoxyphenylamino)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-Dichloropyrimidine (3934-20-1) + 4-methoxy-aniline (104-94-9) → (2-chloropyrimidin-4-yl)(4-methoxyphenyl)amine (191729-02-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; at 50 - 60 ℃;

DOI:10.1039/c4ra02276a

Reference yield: 68.0%

2,6-Dichloropyrimidine (3934-20-1) + 4-methoxy-aniline (104-94-9) → 2-(4-methoxy-aniline)-4-chloro-pyrimidine (925920-90-7) + (2-chloropyrimidin-4-yl)(4-methoxyphenyl)amine (191729-02-9)

Guidance literature:

With triethylamine; In ethanol; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2014.10.061

Reference yield: 85.0%

7-chloro-4-piperazinylquinoline (837-52-5) + (2-chloropyrimidin-4-yl)(4-methoxyphenyl)amine (191729-02-9) → {2-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-4-yl}(4-methoxyphenyl)amine (1454695-39-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 120 ℃;

DOI:10.1039/c4ra02276a

upstream raw materials:

2,6-Dichloropyrimidine

4-methoxy-aniline

Downstream raw materials:

(S)-3-[4-(4-Methoxy-phenylamino)-pyrimidin-2-ylamino]-2-methyl-butan-2-ol

2-chloro-4-(N-(2,6-dimethylphenoxycarbonyl)-N-(4-methoxyphenyl)amino)pyrimidine

N₄-(4-Methoxyphenyl)-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

{2-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-4-yl}(4-methoxyphenyl)amine

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