Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)-

Base Information

• Chemical Name: Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)-
• CAS No.: 1246213-26-2
• Molecular Formula: C19H21NO
• Molecular Weight: 279.382
• Hs Code.: 2926909090
• Mol file: 1246213-26-2.mol

Synonyms:Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)-;2-(2-(Benzyloxy)-5-(tert-butyl)phenyl)acetonitrile

Chemical Property of Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)-

Chemical Property:

• PSA: 33.02000
• LogP: 4.62918

Purity/Quality:

99% ^*data from raw suppliers

2-(2-(Benzyloxy)-5-(tert-butyl)phenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)-

There total 1 articles about Benzeneacetonitrile, 5-(1,1-diMethylethyl)-2-(phenylMethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide + 2-(benzyloxy)-5-tert-butylbenzyl chloride (1246213-43-3) → 2-(benzyloxy)-5-tert-butylbenzyl nitrile (1246213-26-2)

Guidance literature:

In N,N-dimethyl-formamide; at 35 ℃; for 24h; Industry scale;

Reference yield: 100.0%

iodomethane-d3 (865-50-9) + 2-(benzyloxy)-5-tert-butylbenzyl nitrile (1246213-26-2) → 2-(2-(benzyloxy)-5-(tert-butyl)phenyl)-2-(methyl-d3)propanenitrile-3,3,3-d3

Guidance literature:

2-(benzyloxy)-5-tert-butylbenzyl nitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

iodomethane-d3; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1124/jpet.117.241497

Reference yield:

2-(benzyloxy)-5-tert-butylbenzyl nitrile (1246213-26-2) + methyl iodide (74-88-4) → 2-(2-(benzyloxy)-5-tert-butylphenyl)-2-methylpropanenitrile (1246213-27-3)

Guidance literature:

2-(benzyloxy)-5-tert-butylbenzyl nitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 30 ℃; for 3.5h;

upstream raw materials:

2-(benzyloxy)-5-tert-butylbenzyl chloride

Downstream raw materials:

2-(2-(benzyloxy)-5-tert-butylphenyl)-2-methylpropanenitrile