cis-4-(Boc-aMinoMethyl)cyclohexylaMine

Base Information

• Chemical Name: cis-4-(Boc-aMinoMethyl)cyclohexylaMine
• CAS No.: 866548-92-7
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.335
• Hs Code.: 2921309990
• Mol file: 866548-92-7.mol

Synonyms:cis-4-(Boc-aMinoMethyl)cyclohexylaMine;cis-4-(Boc-aMinoMethyl)cy...;tert-Butyl ((cis-4-aminocyclohexyl)methyl)carbamate

Chemical Property of cis-4-(Boc-aMinoMethyl)cyclohexylaMine

Chemical Property:

• PSA: 64.35000
• LogP: 3.11980

Purity/Quality:

97% ^*data from raw suppliers

cis-4-(Boc-aminomethyl)cyclohexylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-4-(Boc-aMinoMethyl)cyclohexylaMine

There total 7 articles about cis-4-(Boc-aMinoMethyl)cyclohexylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(tert-butoxy)-N-({trans-4-[(phenylmethoxy)carbonylamino]cyclohexyl}methyl)carboxamide → tert-butyl ((trans-1,4)-4-aminocyclohexyl)methylcarbamate (866548-92-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 2h;

Reference yield: 91.0%

(tert-butoxy)-N-({trans-4-[(phenylmethoxy)carbonylamino]cyclohexyl}methyl)carboxamide (192323-61-8) → tert-butyl (((1,4-trans)-4-aminocyclohexyl)methyl)carbamate (192323-07-2,866548-92-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 2h;

Reference yield: 82.0%

C13H22N2O3 → tert-butyl (((1,4-trans)-4-aminocyclohexyl)methyl)carbamate (192323-07-2,866548-92-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b01171

upstream raw materials:

(tert-butoxy)-N-({trans-4-[(phenylmethoxy)carbonylamino]cyclohexyl}methyl)carboxamide

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

di-tert-butyl dicarbonate