(2-Ethoxypyridin-3-yl)methanamine

Base Information

• Chemical Name: (2-Ethoxypyridin-3-yl)methanamine
• CAS No.: 851773-43-8
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19368
• Hs Code.: 2933399090
• European Community (EC) Number: 824-315-5
• Mol file: 851773-43-8.mol

Synonyms:851773-43-8;(2-ethoxypyridin-3-yl)methanamine;[(2-ethoxypyridin-3-yl)methyl]amine;2-Ethoxy-3-pyridinemethanamine;(2-ethoxypyridin-3-yl)methylamine;SCHEMBL2600005;BJB77343;MFCD09734870;AKOS000143075;MCULE-5832713813;SB52910;DB-203310;EN300-31178;F78885;1-(2-ethoxy-3-pyridinyl)methanamine(SALTDATA: 2HCl);F2147-1546

Chemical Property of (2-Ethoxypyridin-3-yl)methanamine

Chemical Property:

• PSA: 48.14000
• LogP: 1.63930
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 152.094963011
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

NLT 98% ^*data from raw suppliers

[(2-Ethoxypyridin-3-yl)methyl]amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=CC=N1)CN

Technology Process of (2-Ethoxypyridin-3-yl)methanamine

There total 4 articles about (2-Ethoxypyridin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((2-ethoxypyridin-3-yl)methyl)carbamate (478374-98-0) → (2-ethoxypyridin-3-yl)methanamine (851773-43-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;

Reference yield:

3-bromo-2-chloropyridine (52200-48-3) → (2-ethoxypyridin-3-yl)methanamine (851773-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium tert-butylate / 12 h / 80 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C / Microwave irradiation

3: hydrogen / ethanol / 2 h / 20 °C / 2327.23 Torr

4: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium tert-butylate; hydrogen; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

3-bromo-2-ethoxypyridine (57883-25-7) → (2-ethoxypyridin-3-yl)methanamine (851773-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C / Microwave irradiation

2: hydrogen / ethanol / 2 h / 20 °C / 2327.23 Torr

3: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;

upstream raw materials:

3-bromo-2-ethoxypyridine

2-ethoxynicotinonitrile

tert-butyl ((2-ethoxypyridin-3-yl)methyl)carbamate

3-bromo-2-chloropyridine

Downstream raw materials:

C₂₀H₁₈ClN₃O₂

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