2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE

Base Information

• Chemical Name: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE
• CAS No.: 14248-71-6
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Hs Code.: 2933399090
• Mol file: 14248-71-6.mol

Synonyms:Nicotinonitrile,2-ethoxy- (8CI);

Chemical Property of 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE

Chemical Property:

• Vapor Pressure: 0.0158mmHg at 25°C
• Melting Point: 36-38 °C
• Refractive Index: 1.52
• Boiling Point: 256 °C at 760 mmHg
• Flash Point: 108.6 °C
• PSA: 45.91000
• Density: 1.12 g/cm³
• LogP: 1.35198
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethoxynicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE

There total 5 articles about 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

zinc(II) cyanide (557-21-1) + 3-bromo-2-ethoxypyridine (57883-25-7) → 2-ethoxynicotinonitrile (14248-71-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

2-chloro-3-pyridinecarbonitrile (6602-54-6) + ethanol (64-17-5) → 2-ethoxynicotinonitrile (14248-71-6)

Guidance literature:

With sodium; at 20 ℃; for 18h;

Reference yield:

3-bromo-2-chloropyridine (52200-48-3) → 2-ethoxynicotinonitrile (14248-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 12 h / 80 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one;

upstream raw materials:

2-chloro-3-pyridinecarbonitrile

ethanol

zinc(II) cyanide

3-bromo-2-ethoxypyridine

Downstream raw materials:

(2-ethoxypyridin-3-yl)methanamine

Refernces

• 1、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES". Page/Page column 136. . Retrieved 2019/07/19.
• 2、 -. "1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS". Paragraph 0647-0648. . Retrieved 2019/07/10.