Butanedioic acid, (4-chlorophenyl)-, diethyl ester

Base Information

• Chemical Name: Butanedioic acid, (4-chlorophenyl)-, diethyl ester
• CAS No.: 108005-48-7
• Molecular Formula: C14H17ClO4
• Molecular Weight: 284.73538
• Mol file: 108005-48-7.mol

Synonyms:Butanedioic acid, (4-chlorophenyl)-, diethyl ester;diethyl2-(4-chlorophenyl)succinate

Chemical Property of Butanedioic acid, (4-chlorophenyl)-, diethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 2.93990

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanedioic acid, (4-chlorophenyl)-, diethyl ester

There total 6 articles about Butanedioic acid, (4-chlorophenyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

p-chlorobenzenediazonium tetrafluoroborate (673-41-6) + diethyl Fumarate (623-91-6) → 2-(4-chlorophenyl)succinic acid diethyl ester (108005-48-7)

Guidance literature:

With sodium acetate; titanium(III) chloride; In water; acetone; at 20 ℃;

DOI:10.1055/s-1986-31593

Reference yield:

2-(4-chlorophenyl)buten-2-dioic 1,4-diethylate → 2-(4-chlorophenyl)succinic acid diethyl ester (108005-48-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 60h;

DOI:10.1021/jm0301033

Reference yield:

(Z)-3-(4-chloro-phenyl)-3-cyano-propenoic acid potassium salt → 2-(4-chlorophenyl)succinic acid diethyl ester (108005-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. H₂SO₄ / 6 h / Heating

2: H₂ / Pd/C / ethanol / 60 h / 20 °C

With sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm0301033

upstream raw materials:

p-chlorobenzenediazonium tetrafluoroborate

diethyl Fumarate

p-chlorobenzyl cyanide

ethyl-p-chlorocinnamate

Downstream raw materials:

3-(p-Chlorphenyl)-1,1-dideutero-1-propen

ethyl 3-(4-chlorophenyl)propanoate

2-(4-chlorophenyl)butane-1,4-dimesylate

2-(4-Chloro-phenyl)-butane-1,4-diol