4-Hydroxy-5-nitropyridine-3-carboxylic acid

Base Information

• Chemical Name: 4-Hydroxy-5-nitropyridine-3-carboxylic acid
• CAS No.: 911461-03-5
• Molecular Formula: C6H4N2O5
• Molecular Weight: 184.11
• Hs Code.: 2933399090
• Mol file: 911461-03-5.mol

Synonyms:4-Hydroxy-5-nitropyridine-3-carboxylic acid;4-Hydroxy-3-nitro-5-pyridinecarboxylic acid;4-Hydroxy-5-nitronicotinic acid

Chemical Property of 4-Hydroxy-5-nitropyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 217-219 °C(Solv: ethanol (64-17-5))
• Boiling Point: 478.109°C at 760 mmHg
• PKA: -1.62±0.21(Predicted)
• Flash Point: 242.952°C
• PSA: 116.24000
• Density: 1.746g/cm³
• LogP: 0.91680
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-5-nitronicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-5-nitropyridine-3-carboxylic acid

There total 1 articles about 4-Hydroxy-5-nitropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

4-hydroxynicotinic acid (609-70-1) → 4-hydroxy-5-nitronicotinic acid (911461-03-5)

Guidance literature:

With sulfuric acid; nitric acid; at 100 ℃; for 20h;

DOI:10.1016/j.bmc.2016.08.016

Reference yield:

4-hydroxy-5-nitronicotinic acid (911461-03-5) → 4-amino-5-nitronicotinamide (911461-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / CCl₄; dimethylformamide / 9 h / Heating

2: 0.9 g / ammonia / acetonitrile; H₂O / 0.25 h / 0 °C

With pyridine; thionyl chloride; ammonia; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1007/s11172-006-0057-x

Reference yield:

4-hydroxy-5-nitronicotinic acid (911461-03-5) → 1-(4-(piperazin-1-yl)phenyl)-8,9-dihydro-2,4,7,9a-tetraazabenzo[cd]azulen-6(7H)-one

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 24 h / Reflux

2: triethylamine / dichloromethane / 2 h / -10 °C

3: sodium carbonate / acetonitrile / 24 h / 90 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

5: palladium 10% on activated carbon / methanol / 24 h / 120 °C / Sealed tube

With thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2016.08.016

upstream raw materials:

4-hydroxynicotinic acid

Downstream raw materials:

4-amino-5-nitronicotinamide