609-70-1

Basic information

• Product Name: 4-Hydroxynicotinic acid
• Synonyms: 4-HYDROXY-3-PYRIDINE CARBOXYLIC ACID;4-HYDROXYPYRIDINE-3-CARBOXYLIC ACID;4-HYDROXYNICOTINIC ACID;IFLAB-BB F1371-0219;3`-Carboxy-4-hydroxypyridine;4-HYDROXY NICOTINIC ACID 98.5%;4-Hydroxynicotinic acid ,97%;4-keto-1H-pyridine-3-carboxylic acid
• CAS NO: 609-70-1
• Molecular Formula: C₆H₅NO₃
• Molecular Weight: 139.11
• EINECS: 210-197-7
• Product Categories: blocks;Carboxes;Pyridines
• Mol File: 609-70-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 256-259℃
• Boiling Point: 312.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep Cold
• Solubility: Soluble in 0.1 M NaOH: 0.1 g/mL.
• PKA: 0.19±0.10(Predicted)
• CAS DataBase Reference: 4-Hydroxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxynicotinic acid(609-70-1)
• EPA Substance Registry System: 4-Hydroxynicotinic acid(609-70-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-36/37-24/25
• Hazardous Substances Data: 609-70-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to light yellow solid

Uses

4-Hydroxynicotinic acid, is used as a chemical synthesis reagent. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Definition

ChEBI: An aminonicotinic acid in which the amino group is situated at position 4 of the pyridine ring.

InChI:InChI=1/C6H5NO3/c8-5-1-2-7-3-4(5)6(9)10/h1-3H,(H,7,8)(H,9,10)

Upstream product

• 98645-47-7 4-Ethoxypyridin-3-carbonitril 
• 59-67-6 nicotinic acid 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 67848-59-3 4-piperidone-3-carboxylic acid ethyl ester 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 108554-34-3 methyl 4-oxonipecotate 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 626-61-9 4-Chloropyridine 
• 10177-29-4 4-chloronicotinic acid 
• 271-92-1 furo[3,2-c]pyridine 
• 98645-44-4 2-Brom-4-ethoxypyridin-3-carbonitril 
• 98645-45-5 2-Chlor-4-ethoxypyridin-3-carbonitril 
• 98645-42-2 2-bromo-4-methoxypyridine-3-carbonitrile 
• 98645-43-3 2-chloro-3-cyano-4-methoxypyridine 

Downstream Products

• 10561-89-4 1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1052114-83-6 5-bromo-4-hydroxypyridine-3-carboxylic acid 
• 873054-42-3 N-(3-aminophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1571134-68-3 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid (5-methanesulfonyl(pyridin-2-yl)methyl)amide 
• 1571135-38-0 1-(4-cyanobenzyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1571135-37-9 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 1571135-39-1 5-bromo-1-(4-cyanobenzyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1571134-67-2 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 57659-03-7 6-oxo-1,6-dihydropyridine-3-carbonyl chloride 
• 18103-73-6 4-mercaptopyridine-3-carboxylic acid 
• 7418-63-5 4-hydroxynicotinamide 
• 99514-01-9 4-mercapto-nicotinic acid-(2,4-dichloro-benzylidenehydrazide) 
• 911461-18-2 4-amino-5-nitronicotinamide 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES

The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.

Heterocyclic mutilin esters and their use as antibacterials

Pleuromutilin compounds of the formula: 1are of use in anti-bacterial therapy.