tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate

Base Information

• Chemical Name: tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate
• CAS No.: 1270019-92-5
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Mol file: 1270019-92-5.mol

Synonyms:tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate

Chemical Property of tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate

Chemical Property:

• Boiling Point: 313.4±31.0 °C(Predicted)
• PKA: 12.38±0.40(Predicted)
• PSA: 50.36000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 2.22880

Purity/Quality:

99%, ^*data from raw suppliers

tert-butylN-[(3R,5S)-5-Methylpiperidin-3-yl]carbamatetert-butylN-[(3R,5S)-5-methylpiperidin-3-yl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: tert-butyl N-[(3R,5S)-5-Methylpiperidin-3-yl]carbamatetert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate is used in the synthetic preparation of polycyclic TLR7/8 antagonists towards the treatment of immune disorders.

Technology Process of tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate

There total 7 articles about tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

tert-butyl ((3R,5S)-1-benzyl-5-methylpiperidin-3-yl)carbamate → ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester (1270019-92-5,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 45 ℃; for 7h; under 37503.8 Torr;

Reference yield: 95.0%

tert-butyl ((3R,5S)-5-methylpiperidin-3-yl)carbamate (2R,3R)-2,3-bis((4-methoxybenzolyl)oxy)succinic acid → ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester (1270019-92-5,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 25.0%

(3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester (1270019-95-8,1187055-56-6,1405128-25-7) → ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester (1270019-92-5,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

(3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester; With (2R,3R)-2,3-bis[(4-methoxyphenyl)carbonyloxy]butanedioic acid; In isopropyl alcohol; acetone; at 20 ℃; for 24h;

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 2.5h;

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl N-(5-methylpyridin-3-yl)carbamate

5-methylpyridin-3-amine

(3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

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