TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE
• CAS No.: 1270019-95-8
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.3
• Mol file: 1270019-95-8.mol

Synonyms:N-Boc-5-methylpiperidin-3-amine;TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE;2-Methyl-2-propanyl [(3S,5R)-5-methyl-3-piperidinyl]carbamate;Carbamic acid, N-(5-methyl-3-piperidinyl)-, 1,1-dimethylethyl ester

Chemical Property of TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Tert-Butyl(5-Methylpiperidin-3-Yl)Carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE

There total 53 articles about TERT-BUTYL (5-METHYLPIPERIDIN-3-YL)CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

tert-butyl ((3R,5S)-1-benzyl-5-methylpiperidin-3-yl)carbamate → ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester (1270019-92-5,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 45 ℃; for 7h; under 37503.8 Torr;

Reference yield: 95.0%

tert-butyl ((3R,5S)-5-methylpiperidin-3-yl)carbamate (2R,3R)-2,3-bis((4-methoxybenzolyl)oxy)succinic acid → ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester (1270019-92-5,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 85.8%

tert-butyl [(3S,5R)-1-benzyl-5-methylpiperidin-3-yl]carbamate (1203651-06-2) → tert-butyl ((3S,5R)-5-methylpiperidin-3-yl)carbamate (1203651-07-3,1270019-95-8,1187055-56-6,1405128-25-7)

Guidance literature:

With hydrogen; palladium-carbon; In methanol; at 45 ℃; for 36h;

upstream raw materials:

(3S,5S)-(1-benzyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

methyl iodide

(2S,4S)-2-tert-butoxycarbonylamino-4-methyl-pentanedinitrile

Downstream raw materials:

benzyl [2-{[(4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)amino]carbonyl}-7-(4-methylpiperazin-1-yl)quinolin-3-yl]carbamate

benzyl (7-bromo-2-{[(4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)amino]carbonyl}quinolin-3-yl)carbamate

benzyl [2-{[(4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)amino]carbonyl}-7-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)quinolin-3-yl]carbamate

benzyl [2-{[(4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)amino]carbonyl}-7-(2-oxopiperidin-1-yl)quinolin-3-yl]carbamate

Refernces

• 1、 -. "SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS". Paragraph 0328; 0329. . Retrieved 2020/11/12.
• 2、 Thorarensen, Atli,Dowty, Martin E.,Banker, Mary Ellen,Juba, Brian,Jussif, Jason,Lin, Tsung,Vincent, Fabien,Czerwinski, Robert M.,Casimiro-Garcia, Agustin,Unwalla, Ray,Trujillo, John I.,Liang, Sidney,Balbo, Paul,Che, Ye,Gilbert, Adam M.,Brown, Matthew F.,Hayward, Matthew,Montgomery, Justin,Leung, Louis,Yang, Xin,Soucy, Sarah,Hegen, Martin,Coe, Jotham,Langille, Jonathan,Vajdos, Felix,Chrencik, Jill,Telliez, Jean-Baptiste. "Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans". . p. 1971 - 1993. Retrieved 2017/03/20.