6-broMo-2-naphthaMide

Base Information

• Chemical Name: 6-broMo-2-naphthaMide
• CAS No.: 1255871-55-6
• Molecular Formula: C11H8BrNO
• Molecular Weight: 250.09132
• Mol file: 1255871-55-6.mol

Synonyms:6-broMo-2-naphthaMide

Chemical Property of 6-broMo-2-naphthaMide

Chemical Property:

• Melting Point: 220 °C
• Boiling Point: 452.8±18.0 °C(Predicted)
• PKA: 15.82±0.30(Predicted)
• PSA: 43.09000
• Density: 1.578±0.06 g/cm3(Predicted)
• LogP: 3.40150

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-naphthamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-broMo-2-naphthaMide

There total 2 articles about 6-broMo-2-naphthaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-bromo-2-naphthoic acid (5773-80-8) → 6-bromonaphthalene-2-carboxamide (1255871-55-6)

Guidance literature:

6-bromo-2-naphthoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

With ammonium hydroxide; In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1016/j.bmc.2018.04.042

Reference yield:

6-bromonaphthalene-2-carbonyl chloride (87700-60-5) → 6-bromonaphthalene-2-carboxamide (1255871-55-6)

Guidance literature:

With ammonia; In methanol; dichloromethane; at 20 ℃; for 3h;

Reference yield: 95.0%

6-bromonaphthalene-2-carboxamide (1255871-55-6) → 6-bromo-naphthalene-2-carbonitrile (91065-17-7)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 0.25h;

DOI:10.1016/j.bmc.2018.04.042

upstream raw materials:

6-bromonaphthalene-2-carbonyl chloride

6-bromo-2-naphthoic acid

Downstream raw materials:

6-bromo-naphthalene-2-carbonitrile

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthonitrile

(R)-6-(1-phenylethyl)-2-naphthonitrile

6-[2-(4-methoxy-phenyl)-vinyl]-naphthalene-2-carbonitrile