91065-17-7

Basic information

• Product Name: 6-Bromonaphthalene-2-carbonitrile
• Synonyms: 6-Bromonaphthalene-2-carbonitrile;6-bromo-2-naphthonitrile;6-Bromo-2-cyanonaphthalene;6-BROMONAPHTHALENE-2-CARBONITRILE(WXC08035)
• CAS NO: 91065-17-7
• Molecular Formula: C₁₁H₆BrN
• Molecular Weight: 232.07604
• Mol File: 91065-17-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 160-162 °C
• Boiling Point: 364.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.57±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 6-Bromonaphthalene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromonaphthalene-2-carbonitrile(91065-17-7)
• EPA Substance Registry System: 6-Bromonaphthalene-2-carbonitrile(91065-17-7)

Safety Data

• Hazardous Substances Data: 91065-17-7(Hazardous Substances Data)

Upstream product

• 7499-66-3 6-Bromonaphthalen-2-amine 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 170737-46-9 6-bromo-naphthalene-2-carboxaldehyde 
• 5773-80-8 6-bromo-2-naphthoic acid 
• 87700-60-5 6-bromonaphthalene-2-carbonyl chloride 
• 1255871-55-6 6-bromonaphthalene-2-carboxamide 
• 151600-02-1 6-bromo-2-naphthalenyl trifluoromethanesulfonate 

Downstream Products

• 1255871-58-9 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthonitrile 
• 1424035-61-9 (R)-6-(1-phenylethyl)-2-naphthonitrile 
• 129667-70-5 6-amino-2-naphthalenecarbonitrile 

Relevant articles and documents

Novel amidrazone derivatives: Design, synthesis and activity evaluation

A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound 5e showed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases.

Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes

We have developed a stereospecific nickel-catalyzed cross-coupling of benzylic pivalates with arylboroxines. The success of this reaction relies on the use of Ni(cod)2 as the catalyst and NaOMe as a uniquely effective base. This reaction has broad scope with respect to the arylboroxine and benzylic pivalate, enabling the synthesis of a variety of diarylalkanes and triarylmethanes in good to excellent yields and ee's.

ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of Formula (I); a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.