Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate

Base Information

• Chemical Name: Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate
• CAS No.: 1523570-99-1
• Molecular Formula: C9H16O4
• Molecular Weight: 188.22094
• Mol file: 1523570-99-1.mol

Synonyms:Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate;methyl 3,3-dimethoxy-1-methylcyclobutane-1-carboxylate

Chemical Property of Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl3,3-Dimethoxy-1-methyl-cyclobutanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate

There total 2 articles about Methyl 3,3-diMethoxy-1-Methyl-cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,3-dimethoxycyclobutanecarboxylic acid methyl ester (98231-07-3) + methyl iodide (74-88-4) → methyl 3,3-dimethoxy-1-methylcyclobutanecarboxylate (1523570-99-1)

Guidance literature:

3,3-dimethoxycyclobutanecarboxylic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

DOI:10.1021/acs.orglett.1c03052

Reference yield:

methyl 3-oxocyclobutanecarboxylate (695-95-4) → methyl 3,3-dimethoxy-1-methylcyclobutanecarboxylate (1523570-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / methanol / 2 h / Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; methanol; hexane;

Reference yield: 78.0%

methyl 3,3-dimethoxy-1-methylcyclobutanecarboxylate (1523570-99-1) → 1-methyl-3-oxocyclobutane-1-carboxylic acid (286442-89-5)

Guidance literature:

methyl 3,3-dimethoxy-1-methylcyclobutanecarboxylate; With sodium hydroxide; In ethanol; water; for 0.5h; Reflux;

With hydrogenchloride; In 1,4-dioxane; ethanol; water; at 20 ℃;

DOI:10.1021/acs.orglett.1c03052

upstream raw materials:

3,3-dimethoxycyclobutanecarboxylic acid methyl ester

methyl iodide

methyl 3-oxocyclobutanecarboxylate

Downstream raw materials:

1-methyl-3-oxocyclobutane-1-carboxylic acid