Quinoline, 7-bromo-8-methyl-

Base Information

• Chemical Name: Quinoline, 7-bromo-8-methyl-
• CAS No.: 809248-61-1
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 809248-61-1.mol

Synonyms:Quinoline, 7-bromo-8-methyl-;7-Bromo-8-methylquinoline;7-Bromo-8-methyl-1-azanaphthalene;7-Bromo-8-methylquinoline 95+%

Chemical Property of Quinoline, 7-bromo-8-methyl-

Chemical Property:

• Melting Point: 47-48.5 °C
• Boiling Point: 312.7±22.0 °C(Predicted)
• PKA: 3.47±0.31(Predicted)
• PSA: 12.89000
• Density: 1.488
• LogP: 3.30570
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Methanol (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-8-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Bromo-8-methylquinoline is a derivative of Quinoline (Q700380), a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs.

Technology Process of Quinoline, 7-bromo-8-methyl-

There total 2 articles about Quinoline, 7-bromo-8-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-bromo-2-methylaniline (55289-36-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 7-bromo-8-methyl-quinoline (809248-61-1)

Guidance literature:

With sulfuric acid; water; at 145 ℃; for 3.5h;

DOI:10.1021/ol301739f

Reference yield:

3-bromo-2-methylaniline (55289-36-6) → 7-bromo-8-methyl-quinoline (809248-61-1)

Guidance literature:

Reference yield: 76.0%

7-bromo-8-methyl-quinoline (809248-61-1) + diphenyl acetylene (501-65-5) → 7-bromo-8-(2,3-diphenylallyl)quinoline

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201310711

upstream raw materials:

3-bromo-2-methylaniline

glycerol

Downstream raw materials:

N-((7-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide