2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole]

Base Information

• Chemical Name: 2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole]
• CAS No.: 1204218-41-6
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.206
• Mol file: 1204218-41-6.mol

Synonyms:2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole];Spiro[1,3-dioxolane-2,5'-[5H]indazole], 1',4',6',7'-tetrahydro-;2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole] (CAS# 1204218-41-6;1',4',6',7'-tetrahydrospiro[[1,3]dioxolane-2,5'-indazole]

Chemical Property of 2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole]

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole]

There total 3 articles about 2',4',5',7' - tetrahydrospiro[[1,3]dioxolane - 2,6' - indazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

8-oxo-1,4-dioxa-spiro[4.5]decane-7-carbaldehyde → 1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] (1160245-61-3,1204218-41-6)

Guidance literature:

With hydrazine hydrate; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

7-(hydroxymethylene)-1,4-dioxaspiro-[4.5]decan-8-one (115215-91-3) → 1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] (1160245-61-3,1204218-41-6)

Guidance literature:

With hydrazine; In methanol; water; at 0 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.01.069

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] (1160245-61-3,1204218-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; methanol / 2 h / Reflux

2: hydrazine / methanol; water / 1 h / 0 °C

With sodium hydride; hydrazine; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmcl.2011.01.069

upstream raw materials:

cyclohexanedione monoethylene ketal

7-(hydroxymethylene)-1,4-dioxaspiro-[4.5]decan-8-one

Downstream raw materials:

C₁₄H₁₄N₂O

C₁₇H₂₁N₃O

C₁₈H₂₁N₃O

C₁₉H₂₃N₃O