4746-97-8Relevant articles and documents
Studies on the synthesis of Schisandraceae natural products: Exploring a cyclopropylcarbinol ring expansion strategy
Fischer, Derek,Theodorakis, Emmanuel A.
, p. 4193 - 4196 (2007)
Acid mediated cyclopropylcarbinol ring expansion has been shown to be a viable method for the construction of the AB ring framework of lancifodilactone F and related terpenoids of the Schisandraceae family of natural products. We found that this rearrangement proceeds with good stereochemical control based on inversion of the C10 cyclopropyl center. Our studies indicate that the cis-decalin motif of 31 could be used as a key synthetic precursor of certain Schisandraceae metabolites. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Synthesis method of 1,4-cyclohexanedione monoethylene ketal
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Paragraph 0007; 0026; 0027; 0028; 0029; 0030, (2020/10/21)
The invention relates to the technical field of organic synthesis, and particularly discloses a synthesis method of 1,4-cyclohexanedione monoethylene ketal. The synthesis method comprises the following step: with dimethyl 1,4-cyclohexanedione-2,5-dicarboxylate, ethylene glycol and water as raw materials and acidic ionic liquid as a reaction medium and a catalyst, sequentially carrying out heatingto 105-120 DEG C and 130-140 DEG C for reactions respectively to obtain the 1,4-cyclohexanedione monoethylene glycol ketal. According to the synthesis method disclosed by the invention, one-pot synthesis from dimethyl 1,4-cyclohexanedione-2,5-dicarboxylate to 1,4-cyclohexanedione monoethylene glycol ketal is realized, and the problems of low industrial production efficiency and low yield of 1,4-cyclohexanedione monoethylene glycol ketal in the prior art are solved.
An investigation into the role of 2,6-lutidine as an additive for the RuCl3-NaIO4 mediated oxidative cleavage of olefins to ketones
Watson, David W.,Gill, Matthew,Kemmitt, Paul,Lamont, Scott G.,Popescu, Mihai V.,Simpson, Iain
supporting information, p. 4479 - 4482 (2018/11/23)
2,6-Lutidine has been identified as a beneficial additive for the oxidative cleavage of olefins to ketones by NaIO4 in the presence of catalytic RuCl3, improving the yield and shortening the reaction times. In the absence of 2,6-lutidine reactions stalled at the diol intermediate with incomplete conversion to the desired ketones. The reaction protocol described herein also avoids the use of harmful solvents such as CCl4 and DCE and is tolerant of a range of functional groups.