5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile

Base Information

• Chemical Name: 5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile
• CAS No.: 1108745-07-8
• Molecular Formula: C₁₄H₈F₃NO
• Molecular Weight: 263.219
• Mol file: 1108745-07-8.mol

Synonyms:5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile

Chemical Property of 5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile

There total 1 articles about 5-[(3,5-Difluorophenyl)hydroxymethyl]-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,5-difluorobromobenzene (461-96-1) + 2-fluoro-5-formylbenzonitrile (218301-22-5) → 5-[(3,5-difluoro-phenyl)-hydroxy-methyl]-2-fluoro-benzonitrile (1108745-07-8)

Guidance literature:

3,5-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 90 ℃; for 1h;

2-fluoro-5-formylbenzonitrile; In tetrahydrofuran; at -10 ℃; for 1.5h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 88.0%

5-[(3,5-difluoro-phenyl)-hydroxy-methyl]-2-fluoro-benzonitrile (1108745-07-8) → 5-(3,5-difluorobenzyl)-2-fluorobenzonitrile (1108745-25-0)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.04.024

Reference yield: 77.0%

5-[(3,5-difluoro-phenyl)-hydroxy-methyl]-2-fluoro-benzonitrile (1108745-07-8) → 5-(3,5-difluoro-benzoyl)-2-fluoro-benzonitrile (1108745-09-0)

Guidance literature:

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

3,5-difluorobromobenzene

2-fluoro-5-formylbenzonitrile

Downstream raw materials:

5-(3,5-difluoro-benzoyl)-2-fluoro-benzonitrile

5-(3,5-difluorobenzyl)-2-fluorobenzonitrile